Complex Systems and Computational Biology Approaches to Acute Inflammation by Yoram Vodovotz download in pdf, ePub, iPad
Principal drivers and networks. Both inflammation and associated processes e. However, inflammation is a critical and necessary process that allows organisms to deal with a rapidly changing and often hostile environment, and is not intrinsically detrimental.
By understanding the immune system we can improve vaccination, control autoimmunity and prevent or reverse infectious diseases and cancer. These studies have utilized both mechanistic and data-driven modeling to improve translational research. However, a disregulated immune system is also implicated in many diseases such as diabetes, lupus, multiple sclerosis, rheumatoid arthritis and atherosclerosis. And yet, inflammation is not in and of itself detrimental. Concepts and Practice for the Future of Biomedical Research.
Furthermore, rules-based approaches have also been utilized to model inflammation-related processes. Rather, we wish to reprogram inflammation rationally and in an individualized fashion.
The acute inflammatory response in diverse shock states. Insights from a comparison of mathematical simulations and hepatic transcriptomic analysis. Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure. We suggest that we are on the cusp of fulfilling the promise of in silico modeling for personalized medicine for inflammatory disease.
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